Sintokamide A Is a Novel Antagonist of Androgen Receptor That Uniquely Binds Activation Function-1 in Its Amino-terminal Domain

Androgen receptor (AR) is a validated drug target for all stages of prostate cancer including metastatic castration-resistant prostate cancer (CRPC). All current hormone therapies for CRPC target the C-terminal ligand-binding domain of AR and ultimately all fail with resumed AR transcriptional activ...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Banuelos, Carmen A., Tavakoli, Iran, Tien, Amy H., Caley, Daniel P., Mawji, Nasrin R., Li, Zhenzhen, Wang, Jun, Yang, Yu Chi, Imamura, Yusuke, Yan, Luping, Wen, Jian Guo, Andersen, Raymond J., Sadar, Marianne D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064002/
https://ncbi.nlm.nih.gov/pubmed/27576691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734475
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