Sintokamide A Is a Novel Antagonist of Androgen Receptor That Uniquely Binds Activation Function-1 in Its Amino-terminal Domain

Androgen receptor (AR) is a validated drug target for all stages of prostate cancer including metastatic castration-resistant prostate cancer (CRPC). All current hormone therapies for CRPC target the C-terminal ligand-binding domain of AR and ultimately all fail with resumed AR transcriptional activ...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Banuelos, Carmen A., Tavakoli, Iran, Tien, Amy H., Caley, Daniel P., Mawji, Nasrin R., Li, Zhenzhen, Wang, Jun, Yang, Yu Chi, Imamura, Yusuke, Yan, Luping, Wen, Jian Guo, Andersen, Raymond J., Sadar, Marianne D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064002/
https://ncbi.nlm.nih.gov/pubmed/27576691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734475
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