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Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4

The amyloid precursor protein (APP) is an ubiquitously expressed cell surface protein and a key molecule in the etiology of Alzheimer disease. Amyloidogenic processing of APP through secretases leads to the generation of toxic amyloid β (Aβ) peptides, which are regarded as the molecular cause of the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Paschkowsky, Sandra, Hamzé, Mehdi, Oestereich, Felix, Munter, Lisa Marie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063975/
https://ncbi.nlm.nih.gov/pubmed/27563067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753582
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