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Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4
The amyloid precursor protein (APP) is an ubiquitously expressed cell surface protein and a key molecule in the etiology of Alzheimer disease. Amyloidogenic processing of APP through secretases leads to the generation of toxic amyloid β (Aβ) peptides, which are regarded as the molecular cause of the...
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| I publikationen: | J Biol Chem |
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| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063975/ https://ncbi.nlm.nih.gov/pubmed/27563067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753582 |
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