Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

BACKGROUND: Based on some previous research, the chalcone derivatives exhibited potent xanthine oxidase inhibitory activity, e.g. sappanchalcone (7), with IC(50) value of 3.9 μM, was isolated from Caesalpinia sappan. Therefore, objectives of this research are design and synthesis of 7 and other chal...

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Gepubliceerd in:Springerplus
Hoofdauteurs: Bui, Trung Huu, Nguyen, Nhan Trung, Dang, Phu Hoang, Nguyen, Hai Xuan, Nguyen, Mai Thanh Thi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2016
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063830/
https://ncbi.nlm.nih.gov/pubmed/27795931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-016-3485-6
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