Hydroxylated chalcones with dual properties: xanthine oxidase inhibitors and radical scavengers

In this study, we evaluated the abilities of a series of chalcones to inhibit the activity of the enzyme xanthine oxidase (XO) and to scavenge radicals. 20 mono- and polyhydroxylated chalcone derivatives were synthesized by Claisen-Schmidt condensation reactions and then tested for inhibitory potenc...

Full description

Saved in:
Bibliographic Details
Published in:Bioorg Med Chem
Main Authors: Hofmann, Emily, Webster, Jonathan, Do, Thuy, Kline, Reid, Snider, Lindsey, Hauser, Quintin, Higginbottom, Grace, Campbell, Austin, Ma, Lili, Paula, Stefan
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738094/
https://ncbi.nlm.nih.gov/pubmed/26762836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.12.024
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items