Hydroxylated chalcones with dual properties: xanthine oxidase inhibitors and radical scavengers

In this study, we evaluated the abilities of a series of chalcones to inhibit the activity of the enzyme xanthine oxidase (XO) and to scavenge radicals. 20 mono- and polyhydroxylated chalcone derivatives were synthesized by Claisen-Schmidt condensation reactions and then tested for inhibitory potenc...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Hofmann, Emily, Webster, Jonathan, Do, Thuy, Kline, Reid, Snider, Lindsey, Hauser, Quintin, Higginbottom, Grace, Campbell, Austin, Ma, Lili, Paula, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738094/
https://ncbi.nlm.nih.gov/pubmed/26762836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.12.024
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