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Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

BACKGROUND: Based on some previous research, the chalcone derivatives exhibited potent xanthine oxidase inhibitory activity, e.g. sappanchalcone (7), with IC(50) value of 3.9 μM, was isolated from Caesalpinia sappan. Therefore, objectives of this research are design and synthesis of 7 and other chal...

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Detalhes bibliográficos
Publicado no:Springerplus
Main Authors: Bui, Trung Huu, Nguyen, Nhan Trung, Dang, Phu Hoang, Nguyen, Hai Xuan, Nguyen, Mai Thanh Thi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063830/
https://ncbi.nlm.nih.gov/pubmed/27795931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-016-3485-6
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