Persistence of DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukaemia

Somatic mutation of the DNMT3A gene at the arginine R882 site is common in acute myeloid leukaemia (AML). The prognostic significance of DNMT3A R882 mutation clearance, using traditional diagnostic next generation sequencing (NGS) methods, during complete remission (CR) in AML patients is controvers...

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Bibliografski detalji
Izdano u:Br J Haematol
Glavni autori: Bhatnagar, Bhavana, Eisfeld, Ann-Kathrin, Nicolet, Deedra, Mrózek, Krzysztof, Blachly, James S., Orwick, Shelley, Lucas, David M., Kohlschmidt, Jessica, Blum, William, Kolitz, Jonathan E., Stone, Richard M., Bloomfield, Clara D., Byrd, John C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063708/
https://ncbi.nlm.nih.gov/pubmed/27476855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14254
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