Persistence of DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukaemia

Somatic mutation of the DNMT3A gene at the arginine R882 site is common in acute myeloid leukaemia (AML). The prognostic significance of DNMT3A R882 mutation clearance, using traditional diagnostic next generation sequencing (NGS) methods, during complete remission (CR) in AML patients is controvers...

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Publicado en:Br J Haematol
Autores principales: Bhatnagar, Bhavana, Eisfeld, Ann-Kathrin, Nicolet, Deedra, Mrózek, Krzysztof, Blachly, James S., Orwick, Shelley, Lucas, David M., Kohlschmidt, Jessica, Blum, William, Kolitz, Jonathan E., Stone, Richard M., Bloomfield, Clara D., Byrd, John C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063708/
https://ncbi.nlm.nih.gov/pubmed/27476855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14254
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