Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells

Circular RNAs comprise a poorly understood new class of noncoding RNA. In this study, we used a combination of targeted deletion, high-resolution splicing detection, and single-cell sequencing to deeply probe ASXL1 circular splicing. We found that efficient circular splicing required the canonical t...

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Veröffentlicht in:PLoS One
Hauptverfasser: Koh, Winston, Gonzalez, Veronica, Natarajan, Sivaraman, Carter, Robert, Brown, Patrick O., Gawad, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063410/
https://ncbi.nlm.nih.gov/pubmed/27736885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164085
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