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Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model

BACKGROUND: Mutations in the tumor suppressor gene von Hippel-Lindau (VHL) underlie a hereditary cancer syndrome—VHL disease—and are also frequently observed in sporadic renal cell carcinoma of the clear cell type (ccRCC). VHL disease is characterized by malignant and benign tumors in a few specific...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Bader, Hannah L., Hsu, Tien
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062848/
https://ncbi.nlm.nih.gov/pubmed/27733136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2802-3
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