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Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter

The VHL gatekeeper tumour suppressor gene is inactivated in the familial cancer syndrome von Hippel-Lindau disease and in most sporadic clear cell renal cell carcinomas. Recently the VHL gene product has been identified as a specific component of a SCF-like complex, which regulates proteolytic degra...

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Autors principals: Zatyka, M, Morrissey, C, Kuzmin, I, Lerman, M, Latif, F, Richards, F, Maher, E
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735189/
https://ncbi.nlm.nih.gov/pubmed/12114475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.39.7.463
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