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The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription
The Werner syndrome (WS) is a prototypic adult Mendelian progeroid syndrome in which signs of premature aging are associated with genomic instability and an elevated risk of cancer. The WRN RECQ helicase protein binds and unwinds G-quadruplex (G4) DNA substrates in vitro, and we identified significa...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5062591/ https://ncbi.nlm.nih.gov/pubmed/26984941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw079 |
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