The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription

The Werner syndrome (WS) is a prototypic adult Mendelian progeroid syndrome in which signs of premature aging are associated with genomic instability and an elevated risk of cancer. The WRN RECQ helicase protein binds and unwinds G-quadruplex (G4) DNA substrates in vitro, and we identified significa...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Tang, Weiliang, Robles, Ana I., Beyer, Richard P., Gray, Lucas T., Nguyen, Giang H., Oshima, Junko, Maizels, Nancy, Harris, Curtis C., Monnat, Raymond J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062591/
https://ncbi.nlm.nih.gov/pubmed/26984941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw079
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