A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA, also known as Kennedy's disease) is one of nine neurodegenerative disorders that are caused by expansion of polyglutamine-encoding CAG repeats. Intracellular accumulation of abnormal proteins in these diseases, a pathological hallmark, is associated wit...

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Pubblicato in:Hum Mol Genet
Autori principali: Bott, Laura C., Badders, Nisha M., Chen, Ke-lian, Harmison, George G., Bautista, Elaine, Shih, Charles C.-Y., Katsuno, Masahisa, Sobue, Gen, Taylor, J. Paul, Dantuma, Nico P., Fischbeck, Kenneth H., Rinaldi, Carlo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062587/
https://ncbi.nlm.nih.gov/pubmed/26962150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw073
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