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Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. Patients develop slowly progressive proximal muscle weakness, muscle atrophy and fasciculations. Affected individuals often show gynecomastia, testicular atrophy and red...

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Bibliografische gegevens
Hoofdauteurs: Rinaldi, Carlo, Bott, Laura C, Chen, Ke-lian, Harmison, George G, Katsuno, Masahisa, Sobue, Gen, Pennuto, Maria, Fischbeck, Kenneth H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: ScholarOne 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521783/
https://ncbi.nlm.nih.gov/pubmed/22952056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00271
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