Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. Patients develop slowly progressive proximal muscle weakness, muscle atrophy and fasciculations. Affected individuals often show gynecomastia, testicular atrophy and red...

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Hlavní autoři: Rinaldi, Carlo, Bott, Laura C, Chen, Ke-lian, Harmison, George G, Katsuno, Masahisa, Sobue, Gen, Pennuto, Maria, Fischbeck, Kenneth H
Médium: Artigo
Jazyk:Inglês
Vydáno: ScholarOne 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521783/
https://ncbi.nlm.nih.gov/pubmed/22952056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00271
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