A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA, also known as Kennedy's disease) is one of nine neurodegenerative disorders that are caused by expansion of polyglutamine-encoding CAG repeats. Intracellular accumulation of abnormal proteins in these diseases, a pathological hallmark, is associated wit...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Bott, Laura C., Badders, Nisha M., Chen, Ke-lian, Harmison, George G., Bautista, Elaine, Shih, Charles C.-Y., Katsuno, Masahisa, Sobue, Gen, Taylor, J. Paul, Dantuma, Nico P., Fischbeck, Kenneth H., Rinaldi, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062587/
https://ncbi.nlm.nih.gov/pubmed/26962150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw073
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