The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex

Polyglutamine expansion in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA), an X-linked neuromuscular disease that is fully manifest only in males. It has been suggested that proteins with expanded polyglutamine tracts impair ubiquitin-dependent proteolysis due to their p...

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Publicado no:Sci Rep
Main Authors: Bott, Laura C., Salomons, Florian A., Maric, Dragan, Liu, Yuhong, Merry, Diane, Fischbeck, Kenneth H., Dantuma, Nico P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911547/
https://ncbi.nlm.nih.gov/pubmed/27312068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27703
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