The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects

Blockade of corticotropin-releasing factor receptor 1 (CRF1) suppresses stress-induced alcohol seeking in rodents, but clinical translation remains. Here, we first showed that the CRF1 antagonist verucerfont potently blocks hypothalamic-pituitary adrenal (HPA) axis activation in adrenalectomized rat...

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Опубликовано в: :Neuropsychopharmacology
Главные авторы: Schwandt, Melanie L, Cortes, Carlos R, Kwako, Laura E, George, David T, Momenan, Reza, Sinha, Rajita, Grigoriadis, Dimitri E, Pich, Emilio Merlo, Leggio, Lorenzo, Heilig, Markus
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061889/
https://ncbi.nlm.nih.gov/pubmed/27109623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.61
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