The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: A human experimental study

RATIONALE: Post-traumatic stress disorder (PTSD) and alcoholism are frequently co-morbid, suggesting the possibility of overlapping neural substrates. The neurokinin 1 (NK1) receptor for Substance P (SP) has been implicated in both stress- and alcohol-related behaviors. The NK1 antagonist aprepitant...

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Publicat a:Psychopharmacology (Berl)
Autors principals: Kwako, Laura E., George, David T., Schwandt, Melanie L., Spagnolo, Primavera A., Momenan, Reza, Hommer, Daniel W., Diamond, Christine A., Sinha, Rajita, Shaham, Yavin, Heilig, Markus
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512162/
https://ncbi.nlm.nih.gov/pubmed/25030801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3665-4
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