The Corticotropin Releasing Hormone-1 (CRH1) Receptor Antagonist Pexacerfont in Alcohol Dependence: A Randomized Controlled Experimental Medicine Study

Extensive preclinical data implicate corticotropin-releasing hormone (CRH), acting through its CRH1 receptor, in stress- and dependence-induced alcohol seeking. We evaluated pexacerfont, an orally available, brain penetrant CRH1 antagonist for its ability to suppress stress-induced alcohol craving a...

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Detalles Bibliográficos
Publicado en:Neuropsychopharmacology
Main Authors: Kwako, Laura E, Spagnolo, Primavera A, Schwandt, Melanie L, Thorsell, Annika, George, David T, Momenan, Reza, Rio, Daniel E, Huestis, Marilyn, Anizan, Sebastien, Concheiro, Marta, Sinha, Rajita, Heilig, Markus
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367465/
https://ncbi.nlm.nih.gov/pubmed/25409596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.306
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