The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer

The availability of bromodomain and extra-terminal inhibitors (BETi) has enabled translational epigenetic studies in cancer. BET proteins regulate transcription by selectively recognizing acetylated lysine residues on chromatin. BETi compete with this process leading to both downregulation and upreg...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: da Motta, L L, Ledaki, I, Purshouse, K, Haider, S, De Bastiani, M A, Baban, D, Morotti, M, Steers, G, Wigfield, S, Bridges, E, Li, J-L, Knapp, S, Ebner, D, Klamt, F, Harris, A L, McIntyre, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061082/
https://ncbi.nlm.nih.gov/pubmed/27292261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.184
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados