Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids

The pyridine ring is a potent pharmacophore in alkaloid natural products. Nonetheless, its biosynthetic pathways are poorly understood. Rubrolones A and B are tropolone alkaloid natural products possessing a unique tetra-substituted pyridine moiety. Here, we report the gene cluster and propose a bio...

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Published in:Nat Commun
Main Authors: Yan, Yijun, Yang, Jing, Yu, Zhiyin, Yu, Mingming, Ma, Ya-Tuan, Wang, Li, Su, Can, Luo, Jianying, Horsman, Geoffrey P., Huang, Sheng-Xiong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059770/
https://ncbi.nlm.nih.gov/pubmed/27713400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13083
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