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Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
The pyridine ring is a potent pharmacophore in alkaloid natural products. Nonetheless, its biosynthetic pathways are poorly understood. Rubrolones A and B are tropolone alkaloid natural products possessing a unique tetra-substituted pyridine moiety. Here, we report the gene cluster and propose a bio...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5059770/ https://ncbi.nlm.nih.gov/pubmed/27713400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13083 |
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