Loss of immune tolerance to IL-2 in type 1 diabetes

Type 1 diabetes (T1D) is characterized by a chronic, progressive autoimmune attack against pancreas-specific antigens, effecting the destruction of insulin-producing β-cells. Here we show interleukin-2 (IL-2) is a non-pancreatic autoimmune target in T1D. Anti-IL-2 autoantibodies, as well as T cells...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Pérol, Louis, Lindner, John M., Caudana, Pamela, Nunez, Nicolas Gonzalo, Baeyens, Audrey, Valle, Andrea, Sedlik, Christine, Loirat, Delphine, Boyer, Olivier, Créange, Alain, Cohen, José Laurent, Rogner, Ute Christine, Yamanouchi, Jun, Marchant, Martine, Leber, Xavier Charles, Scharenberg, Meike, Gagnerault, Marie-Claude, Mallone, Roberto, Battaglia, Manuela, Santamaria, Pere, Hartemann, Agnès, Traggiai, Elisabetta, Piaggio, Eliane
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059699/
https://ncbi.nlm.nih.gov/pubmed/27708334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13027
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