Loss of immune tolerance to IL-2 in type 1 diabetes

Type 1 diabetes (T1D) is characterized by a chronic, progressive autoimmune attack against pancreas-specific antigens, effecting the destruction of insulin-producing β-cells. Here we show interleukin-2 (IL-2) is a non-pancreatic autoimmune target in T1D. Anti-IL-2 autoantibodies, as well as T cells...

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Pubblicato in:Nat Commun
Autori principali: Pérol, Louis, Lindner, John M., Caudana, Pamela, Nunez, Nicolas Gonzalo, Baeyens, Audrey, Valle, Andrea, Sedlik, Christine, Loirat, Delphine, Boyer, Olivier, Créange, Alain, Cohen, José Laurent, Rogner, Ute Christine, Yamanouchi, Jun, Marchant, Martine, Leber, Xavier Charles, Scharenberg, Meike, Gagnerault, Marie-Claude, Mallone, Roberto, Battaglia, Manuela, Santamaria, Pere, Hartemann, Agnès, Traggiai, Elisabetta, Piaggio, Eliane
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059699/
https://ncbi.nlm.nih.gov/pubmed/27708334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13027
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