Loss of immune tolerance to IL-2 in type 1 diabetes

Type 1 diabetes (T1D) is characterized by a chronic, progressive autoimmune attack against pancreas-specific antigens, effecting the destruction of insulin-producing β-cells. Here we show interleukin-2 (IL-2) is a non-pancreatic autoimmune target in T1D. Anti-IL-2 autoantibodies, as well as T cells...

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izdano v:Nat Commun
Main Authors: Pérol, Louis, Lindner, John M., Caudana, Pamela, Nunez, Nicolas Gonzalo, Baeyens, Audrey, Valle, Andrea, Sedlik, Christine, Loirat, Delphine, Boyer, Olivier, Créange, Alain, Cohen, José Laurent, Rogner, Ute Christine, Yamanouchi, Jun, Marchant, Martine, Leber, Xavier Charles, Scharenberg, Meike, Gagnerault, Marie-Claude, Mallone, Roberto, Battaglia, Manuela, Santamaria, Pere, Hartemann, Agnès, Traggiai, Elisabetta, Piaggio, Eliane
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059699/
https://ncbi.nlm.nih.gov/pubmed/27708334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13027
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