Loss of immune tolerance to IL-2 in type 1 diabetes

Type 1 diabetes (T1D) is characterized by a chronic, progressive autoimmune attack against pancreas-specific antigens, effecting the destruction of insulin-producing β-cells. Here we show interleukin-2 (IL-2) is a non-pancreatic autoimmune target in T1D. Anti-IL-2 autoantibodies, as well as T cells...

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Publicado no:Nat Commun
Main Authors: Pérol, Louis, Lindner, John M., Caudana, Pamela, Nunez, Nicolas Gonzalo, Baeyens, Audrey, Valle, Andrea, Sedlik, Christine, Loirat, Delphine, Boyer, Olivier, Créange, Alain, Cohen, José Laurent, Rogner, Ute Christine, Yamanouchi, Jun, Marchant, Martine, Leber, Xavier Charles, Scharenberg, Meike, Gagnerault, Marie-Claude, Mallone, Roberto, Battaglia, Manuela, Santamaria, Pere, Hartemann, Agnès, Traggiai, Elisabetta, Piaggio, Eliane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059699/
https://ncbi.nlm.nih.gov/pubmed/27708334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13027
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