Thapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent for esophageal squamous cell carcinoma (ESCC). Forced expression of CHOP, one of the key downstream transcription factors during endoplasmic reticulum (ER) stress, upregulates the death receptor 5 (DR5) l...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Ma, Zhiqiang, Fan, Chongxi, Yang, Yang, Di, Shouyin, Hu, Wei, Li, Tian, Zhu, Yifang, Han, Jing, Xin, Zhenlong, Wu, Guiling, Zhao, Jing, Li, Xiaofei, Yan, Xiaolong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059685/
https://ncbi.nlm.nih.gov/pubmed/27731378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35196
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