PERK/eIF-2α/CHOP Pathway Dependent ROS Generation Mediates Butein-induced Non-small-cell Lung Cancer Apoptosis and G2/M Phase Arrest

Butein, a member of the chalcone family, is a potent anticarcinogen against multiple cancers, but its specific anti-NSCLC mechanism remains unknown. The present study examined the effects of butein treatment on NSCLC cell lines and NSCLC xenografts. Butein markedly decreased NSCLC cell viability; in...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Biol Sci
Hauptverfasser: Di, Shouyin, Fan, Chongxi, Ma, Zhiqiang, Li, Mingyang, Guo, Kai, Han, Donghui, Li, Xiaofei, Mu, Deguang, Yan, Xiaolong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643215/
https://ncbi.nlm.nih.gov/pubmed/31360107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.33790
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