Dynamics of mTORC1 activation in response to amino acids

Amino acids are essential activators of mTORC1 via a complex containing RAG GTPases, RAGULATOR and the vacuolar ATPase. Sensing of amino acids causes translocation of mTORC1 to lysosomes, an obligate step for activation. To examine the spatial and temporal dynamics of this translocation, we used liv...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Manifava, Maria, Smith, Matthew, Rotondo, Sergio, Walker, Simon, Niewczas, Izabella, Zoncu, Roberto, Clark, Jonathan, Ktistakis, Nicholas T
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059141/
https://ncbi.nlm.nih.gov/pubmed/27725083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19960
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