Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis

BACKGROUND: Melioidosis, caused by the gram-negative bacterium Burkholderia pseudomallei, is a common cause of community-acquired sepsis in Southeast Asia and Northern Australia. The NLRP3 inflammasome and its downstream product interleukin-1 beta (IL-1β) have been proposed to play crucial roles in...

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Sparad:
Bibliografiska uppgifter
I publikationen:Shock
Huvudupphovsmän: Weehuizen, Tassili A. F., Lankelma, Jacqueline M., De Jong, Hanna K., De Boer, Onno J., Roelofs, Joris J. T. H., Day, Nicholas P., Gram, Hermann, De Vos, Alex F., Wiersinga, W. Joost
Materialtyp: Artigo
Språk:Inglês
Publicerad: Lippincott Williams & Wilkins 2016
Ämnen:
Basic Science Aspects
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058638/
https://ncbi.nlm.nih.gov/pubmed/27219859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000625
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