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Pulmonary pharmacodynamics of an anti-GM-CSFRα antibody enables therapeutic dosing that limits exposure in the lung

Pulmonary alveolar proteinosis is associated with impaired alveolar macrophage differentiation due to genetic defects in the granulocyte macrophage colony-stimulating factor (GM-CSF) axis or autoantibody blockade of GM-CSF. The anti-GM-CSFRα antibody mavrilimumab has shown clinical benefit in patien...

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Publicat a:MAbs
Autors principals: Campbell, Jamie, Nys, Josquin, Eghobamien, Laura, Cohen, E. Suzanne, Robinson, Matthew J., Sleeman, Matthew A.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058617/
https://ncbi.nlm.nih.gov/pubmed/27560702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1215790
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