STAT3-Activated GM-CSFRα Translocates to the Nucleus and Protects CLL Cells from Apoptosis

Here it was determined that Chronic Lymphocytic Leukemia (CLL) cells express the α-subunit but not the β-subunit of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR/CSF3R). GM-CSFRα was detected on the surface, in the cytosol, and the nucleus of CLL cells via confocal microscop...

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Hoofdauteurs: Li, Ping, Harris, David, Liu, Zhiming, Rozovski, Uri, Ferrajoli, Alessandra, Wang, Yongtao, Bueso-Ramos, Carlos, Hazan-Halevy, Inbal, Grgurevic, Srdana, Wierda, William, Burger, Jan, O'Brien, Susan, Faderl, Stefan, Keating, Michael, Estrov, Zeev
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163508/
https://ncbi.nlm.nih.gov/pubmed/24836891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0652-T
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