Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

While reviewing chronic lymphocytic leukemia (CLL) bone marrow slides we identified cytoplasmic lipid vacuoles in CLL cells but not in normal B cells. Because lipoprotein lipase (LPL), which catalyzes hydrolysis of triglycerides into free fatty acids (FFAs), is aberrantly expressed in CLL, we invest...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Rozovski, Uri, Grgurevic, Srdana, Bueso-Ramos, Carlos, Harris, David M., Li, Ping, Liu, Zhiming, Wu, Ji Yuan, Jain, Preetesh, Wierda, William, Burger, Jan, O’Brien, Susan, Jain, Nitin, Ferrajoli, Alessandra, Keating, Michael J., Estrov, Zeev
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433415/
https://ncbi.nlm.nih.gov/pubmed/25733697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0412
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