Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

While reviewing chronic lymphocytic leukemia (CLL) bone marrow slides we identified cytoplasmic lipid vacuoles in CLL cells but not in normal B cells. Because lipoprotein lipase (LPL), which catalyzes hydrolysis of triglycerides into free fatty acids (FFAs), is aberrantly expressed in CLL, we invest...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Res
Main Authors: Rozovski, Uri, Grgurevic, Srdana, Bueso-Ramos, Carlos, Harris, David M., Li, Ping, Liu, Zhiming, Wu, Ji Yuan, Jain, Preetesh, Wierda, William, Burger, Jan, O’Brien, Susan, Jain, Nitin, Ferrajoli, Alessandra, Keating, Michael J., Estrov, Zeev
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433415/
https://ncbi.nlm.nih.gov/pubmed/25733697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0412
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