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Complement dependent cytotoxicity (CDC) in chronic lymphocytic leukemia (CLL): Ofatumumab enhances alemtuzumab CDC and reveals cells resistant to activated complement
Complement dependent cytotoxicity (CDC) is an important mechanism of action for monoclonal antibodies (mAb) used in the treatment of chronic lymphocytic leukemia (CLL). We hypothesized that alemtuzumab (ALM) mediated CDC would be increased by addition of ofatumumab (OFA). CLL cells from 21 previousl...
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出版年: | Leuk Lymphoma |
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主要な著者: | , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2012
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5058513/ https://ncbi.nlm.nih.gov/pubmed/22475085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2012.681657 |
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