Genetic dissection of the α-globin super-enhancer in vivo

Many genes determining cell identity are regulated by clusters of mediator-bound enhancer elements collectively referred to as super-enhancers. These have been proposed to manifest higher-order properties important in development and disease. Here, we report a comprehensive functional dissection of...

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Publicado no:Nat Genet
Main Authors: Hay, Deborah, Hughes, Jim R., Babbs, Christian, Davies, James O.J., Graham, Bryony J., Hanssen, Lars, Kassouf, Mira T., Marieke Oudelaar, A. Marieke, Sharpe, Jacqueline A, Suciu, Maria C., Telenius, Jelena, Williams, Ruth, Rode, Christina, Li, Pik-Shan, Pennacchio, Len A., Sloane-Stanley, Jacqueline A., Ayyub, Helena, Butler, Sue, Sauka-Spengler, Tatjana, Gibbons, Richard J., Smith, Andrew J.H., Wood, William G., Higgs, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058437/
https://ncbi.nlm.nih.gov/pubmed/27376235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3605
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