Genetic dissection of the α-globin super-enhancer in vivo

Many genes determining cell identity are regulated by clusters of mediator-bound enhancer elements collectively referred to as super-enhancers. These have been proposed to manifest higher-order properties important in development and disease. Here, we report a comprehensive functional dissection of...

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Библиографические подробности
Опубликовано в: :Nat Genet
Главные авторы: Hay, Deborah, Hughes, Jim R., Babbs, Christian, Davies, James O.J., Graham, Bryony J., Hanssen, Lars, Kassouf, Mira T., Marieke Oudelaar, A. Marieke, Sharpe, Jacqueline A, Suciu, Maria C., Telenius, Jelena, Williams, Ruth, Rode, Christina, Li, Pik-Shan, Pennacchio, Len A., Sloane-Stanley, Jacqueline A., Ayyub, Helena, Butler, Sue, Sauka-Spengler, Tatjana, Gibbons, Richard J., Smith, Andrew J.H., Wood, William G., Higgs, Douglas R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058437/
https://ncbi.nlm.nih.gov/pubmed/27376235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3605
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