Tissue-specific CTCF/Cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

The genome is organised via CTCF/Cohesin binding sites, which partition chromosomes into 1-5Mb topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ~80kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ~1Mb TAD. We...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Hanssen, Lars L P, Kassouf, Mira T, Oudelaar, A Marieke, Biggs, Daniel, Preece, Chris, Downes, Damien J, Gosden, Matthew, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Hughes, Jim R, Davies, Benjamin, Higgs, Douglas R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540176/
https://ncbi.nlm.nih.gov/pubmed/28737770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3573
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