TCPTP-deficiency in muscle does not alter insulin signalling and glucose homeostasis

AIMS/HYPOTHESIS: Insulin activates the insulin receptor (IR) protein tyrosine kinase and downstream phosphatidylinositol-3-kinase (PI3K)/Akt signalling in muscle to promote glucose uptake. The IR can serve as a substrate for the protein tyrosine phosphatases (PTP) 1B and TCPTP, which share a strikin...

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Bibliografiska uppgifter
I publikationen:Diabetologia
Huvudupphovsmän: Loh, Kim, Merry, Troy L., Galic, Sandra, Wu, Ben J., Watt, Matthew J., Zhang, Sheng, Zhang, Zhong-Yin, Neel, Benjamin G., Tiganis, Tony
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5057388/
https://ncbi.nlm.nih.gov/pubmed/22124607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-011-2386-z
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