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TCPTP-deficiency in muscle does not alter insulin signalling and glucose homeostasis
AIMS/HYPOTHESIS: Insulin activates the insulin receptor (IR) protein tyrosine kinase and downstream phosphatidylinositol-3-kinase (PI3K)/Akt signalling in muscle to promote glucose uptake. The IR can serve as a substrate for the protein tyrosine phosphatases (PTP) 1B and TCPTP, which share a strikin...
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| 出版年: | Diabetologia |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5057388/ https://ncbi.nlm.nih.gov/pubmed/22124607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-011-2386-z |
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