Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

In obesity, anorectic responses to leptin are diminished, giving rise to the concept of ‘leptin resistance’. Increased expression of protein tyrosine phosphatase 1B (PTP1B) has been associated with the attenuation of leptin signaling and development of cellular leptin resistance. Here we report that...

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Hauptverfasser: Loh, Kim, Fukushima, Atsushi, Zhang, Xinmei, Galic, Sandra, Briggs, Dana, Enriori, Pablo J., Simonds, Stephanie, Wiede, Florian, Reichenbach, Alexander, Hauser, Christine, Sims, Natalie A., Bence, Kendra K., Zhang, Sheng, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263335/
https://ncbi.nlm.nih.gov/pubmed/22000926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.09.011
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