Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease

The disease-modifying effects of target of rapamycin complex 1 (TORC1) inhibitors during different stages of polycystic kidney disease (PKD) are not well defined. In this study, male Lewis Polycystic Kidney Disease (LPK) rats (a genetic ortholog of human NPHP9, phenotypically characterised by diffus...

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Publicat a:PLoS One
Autors principals: Ta, Michelle H. T., Schwensen, Kristina G., Foster, Sheryl, Korgaonkar, Mayuresh, Ozimek-Kulik, Justyna E., Phillips, Jacqueline K., Peduto, Anthony, Rangan, Gopala K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056751/
https://ncbi.nlm.nih.gov/pubmed/27723777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164193
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