Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease

The disease-modifying effects of target of rapamycin complex 1 (TORC1) inhibitors during different stages of polycystic kidney disease (PKD) are not well defined. In this study, male Lewis Polycystic Kidney Disease (LPK) rats (a genetic ortholog of human NPHP9, phenotypically characterised by diffus...

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Опубликовано в: :PLoS One
Главные авторы: Ta, Michelle H. T., Schwensen, Kristina G., Foster, Sheryl, Korgaonkar, Mayuresh, Ozimek-Kulik, Justyna E., Phillips, Jacqueline K., Peduto, Anthony, Rangan, Gopala K.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056751/
https://ncbi.nlm.nih.gov/pubmed/27723777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164193
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