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Cytokinetic effects of Wee1 disruption in pancreatic cancer

The Wee1 kinase, which is activated in response to DNA damage, regulates exit from G2 through inhibitory phosphorylation of Cdk1/Cdc2, and is an attractive drug target. However, recent work has highlighted effects of Cdk2 phosphorylation by Wee1 on movement through S-phase, suggesting the potential...

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Bibliografische gegevens
Gepubliceerd in:Cell Cycle
Hoofdauteurs: Chang, Qing, Chandrashekhar, Megha, Ketela, Troy, Fedyshyn, Yaroslav, Moffat, Jason, Hedley, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056606/
https://ncbi.nlm.nih.gov/pubmed/26890070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1138188
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