Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking

While having tremendous potential as therapeutic and imaging tools, the clinical use of engineered nanoparticles has been associated with serious safety concerns. Activation of the complement cascade and the release of proinflammatory factors C3a and C5a may contribute to infusion-related reactions,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wang, Guankui, Chen, Fangfang, Banda, Nirmal K., Holers, V. Michael, Wu, LinPing, Moghimi, S. Moein, Simberg, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056169/
https://ncbi.nlm.nih.gov/pubmed/27777575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00418
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