Paradoxical delay of senescence upon depletion of BRCA2 in telomerase‐deficient worms

BRCA2 is a multifunctional tumor suppressor involved in homologous recombination (HR), mitotic checkpoint regulation, and telomere homeostasis. Absence of Brca2 in mice results in progressive shortening of telomeres and senescence, yet cells are prone to neoplastic transformation with elongated telo...

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Vydáno v:FEBS Open Bio
Hlavní autoři: Kwon, Mi‐Sun, Min, Jaewon, Jeon, Hee‐Yeon, Hwang, Kwangwoo, Kim, Chuna, Lee, Junho, Joung, Je‐Gun, Park, Woong‐Yang, Lee, Hyunsook
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055038/
https://ncbi.nlm.nih.gov/pubmed/27761361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12109
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