The Breast Cancer Susceptibility Gene BRCA2 Is Required for the Maintenance of Telomere Homeostasis

Inactivating mutations in the breast cancer susceptibility gene BRCA2 cause gross chromosomal rearrangements. Chromosome structural instability in the absence of BRCA2 is thought to result from defective homology-directed DNA repair. Here, we show that BRCA2 links the fidelity of telomere maintenanc...

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Autors principals: Min, Jaewon, Choi, Eun Shik, Hwang, Kwangwoo, Kim, Jimi, Sampath, Srihari, Venkitaraman, Ashok R., Lee, Hyunsook
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281639/
https://ncbi.nlm.nih.gov/pubmed/22187435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.278994
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