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Paradoxical delay of senescence upon depletion of BRCA2 in telomerase‐deficient worms
BRCA2 is a multifunctional tumor suppressor involved in homologous recombination (HR), mitotic checkpoint regulation, and telomere homeostasis. Absence of Brca2 in mice results in progressive shortening of telomeres and senescence, yet cells are prone to neoplastic transformation with elongated telo...
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| Publicado no: | FEBS Open Bio |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055038/ https://ncbi.nlm.nih.gov/pubmed/27761361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12109 |
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