A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis

The N-glycan of the IgG constant region (Fc) plays a central role in tuning and directing multiple antibody functions in vivo, including antibody-dependent cellular cytotoxicity, complement deposition, and the regulation of inflammation, among others. However, traditional methods of N-glycan analysi...

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Pubblicato in:J Immunol Methods
Autori principali: Mahan, Alison E, Tedesco, Jacquelynne, Dionne, Kendall, Baruah, Kavitha, Cheng, Hao D., De Jager, Philip L., Barouch, Dan H., Suscovich, Todd, Ackerman, Margaret, Cripsin, Max, Alter, Galit
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054724/
https://ncbi.nlm.nih.gov/pubmed/25523925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2014.12.004
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