Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

HIV-specific broadly neutralizing antibodies (bNAbs) confer protection after passive immunization, but the immunological mechanisms that drive their development are poorly understood. Structural features of bNAbs indicate that they originate from extensive germinal center (GC) selection, which relie...

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Dettagli Bibliografici
Pubblicato in:Sci Immunol
Autori principali: Lofano, Giuseppe, Gorman, Matthew J., Yousif, Ashraf S., Yu, Wen-Han, Fox, Julie M., Dugast, Anne-Sophie, Ackerman, Margaret E., Suscovich, Todd J., Weiner, Joshua, Barouch, Dan, Streeck, Hendrik, Little, Susan, Smith, Davey, Richman, Douglas, Lauffenburger, Douglas, Walker, Bruce D., Diamond, Michael S., Alter, Galit
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2018
Soggetti:
HIV
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298214/
https://ncbi.nlm.nih.gov/pubmed/30120121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aat7796
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