Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

HIV-specific broadly neutralizing antibodies (bNAbs) confer protection after passive immunization, but the immunological mechanisms that drive their development are poorly understood. Structural features of bNAbs indicate that they originate from extensive germinal center (GC) selection, which relie...

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Опубликовано в: :Sci Immunol
Главные авторы: Lofano, Giuseppe, Gorman, Matthew J., Yousif, Ashraf S., Yu, Wen-Han, Fox, Julie M., Dugast, Anne-Sophie, Ackerman, Margaret E., Suscovich, Todd J., Weiner, Joshua, Barouch, Dan, Streeck, Hendrik, Little, Susan, Smith, Davey, Richman, Douglas, Lauffenburger, Douglas, Walker, Bruce D., Diamond, Michael S., Alter, Galit
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2018
Предметы:
HIV
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298214/
https://ncbi.nlm.nih.gov/pubmed/30120121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aat7796
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