The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)

Heparin-induced thrombocytopenia is a prothrombotic disorder caused by antibodies to platelet factor 4 (PF4)/heparin complexes. The mechanism that incites such prevalent anti-PF4/heparin antibody production in more than 50% of patients exposed to heparin in some clinical settings is poorly understoo...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Khandelwal, Sanjay, Lee, Grace M., Hester, C. Garren, Poncz, Mortimer, McKenzie, Steven E., Sachais, Bruce S., Rauova, Lubica, Kelsoe, Garnett, Cines, Douglas B., Frank, Michael, Arepally, Gowthami M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054694/
https://ncbi.nlm.nih.gov/pubmed/27412887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-709634
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