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The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance

BACKGROUND: Dysregulation of the canonical Wnt signaling pathway has been implicated in colorectal cancer (CRC) development as well as incipient stages of malignant transformation. In this study, we investigated the antitumor effects of AZ1366 (a novel tankyrase inhibitor) as a single agent and in c...

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發表在:Oncotarget
Main Authors: Quackenbush, Kevin S., Bagby, Stacey, Tai, Wai Meng, Messersmith, Wells A., Schreiber, Anna, Greene, Justin, Kim, Jihye, Wang, Guoliang, Purkey, Alicia, Pitts, Todd M., Nguyen, Anna, Gao, Dexiang, Blatchford, Patrick, Capasso, Anna, Schuller, Alwin G., Eckhardt, S. Gail, Arcaroli, John J.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053726/
https://ncbi.nlm.nih.gov/pubmed/27070088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8626
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